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2012, vol. 9, br. 2, str. 62-66
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Istorijat tehnološkog razvoja citogenetike
History of technological development of cytogenetics
Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija
Sažetak
Broj ljudskih hromozoma je otkriven 1956. Od tada je prošlo više od pedeset godina i razvijene su novije tehnike počevši od konvencionalnih povezujućih tehnika pa sve do niza molekularnih komparativnih genomskih hibridizacija koje se koriste i danas. Kombinacijom ovih konvencionalnih i molekularnih tehnika, citogenetika je postala nezamenljiv alat za dijagnostiku različitih genetskih poremećaja, utabajući put za moguće tretmane i upravljanje. Ovaj rad prikazuje istoriju i evoluciju citogenetike sve do trenutnog stanja tehnologije.
Abstract
Number of human chromosomes was discovered in 1956. Since then 50 years have passed and newer techniques have been developed since then, ranging from the initial conventional banding techniques to the currently used molecular array comparative genomic hybridization. With a combination of these conventional and molecular techniques, cytogenetics has become an indispensable tool for the diagnosis of various genetic disorders, paving the way for possible treatment and management. This paper traces the history and evolution of cytogenetics leading up to the current state of technology.
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